ISO 16186:2021 履物—履物および履物の構成要素に潜在的に存在する重要な物質—フマル酸ジメチル（DMFU）の測定 | ページ 2

Foreword

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The procedures used to develop this document and those intended for its further maintenance are described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types of ISO documents should be noted. This document was drafted in accordance with the editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives).

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This document was prepared by Technical Committee ISO/TC 216, Footwear, in collaboration with the European Committee for Standardization (CEN) Technical Committee CEN/TC 309, Footwear, in accordance with the Agreement on technical cooperation between ISO and CEN (Vienna Agreement).

This first edition of ISO 16186 cancels and replaces ISO/TS 16186:2012, which has been technically revised.

The main changes compared to the previous edition are as follows:

• new Clause 3, 6.6, 6.8, 6.9 ;
• gas chromatograph with tandem quadrupole mass spectrometer (GC-MS/MS) ;
• Clause 7, desiccant treated as a note ;
• 8.2.2, new clean up procedure;
• new Annexes A, B and C;
• Tabled D.1 aligned with Table D.2;
• bibliography added.

Introduction

Dimethyl fumarate (DMFU) has been found to be a sensitizer at very low concentrations, producing extensive, pronounced eczema, which is difficult to treat.

There are regulations that limit the use of DMFU. For example in the EU, products, or any parts thereof, containing DMFU in concentrations greater than 0,1 mg/kg are not authorized on the market^[3].

1 Scope

This document specifies a method for the determination of the content of dimethyl fumarate (DMFU) by gas chromatograph with single quadrupole mass spectrometer (GC-MS) or tandem quadrupole mass spectrometer (GC-MS/MS).

This document is applicable to all types of footwear and footwear components except metal parts.

2 Normative references

The following documents are referred to in the text in such a way that some or all of their content constitutes requirements of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.

3 Terms and definitions

No terms and definitions are listed in this document.

ISO and IEC maintain terminological databases for use in standardization at the following addresses:

Bibliography